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Rather than depicting the typical clenched hand seen in post-stroke muscular spasticity, the picture suggests an alternative diagnosis such as ulnar palsy, commonly known as “claw hand.” [. . .] This may explain why he left numerous paintings incomplete, including the Mona Lisa, during the last five years of his career as a painter, while he continued teaching and drawing.
One cannot indeed expect any more good work from him as a certain paralysis has crippled his right hand. [. . .] And although Messer Leonardo can no longer paint with the sweetness which was peculiar to him, he can still design and instruct others.